Effects of total flavonoids of raspberry on perimenopausal model in mice

This study tested how total flavonoids from raspberries affected mice that had been surgically altered to mimic the hormonal changes of the perimenopausal transition (the period leading into menopause). Flavonoids are plant compounds found in fruits like raspberries that act as antioxidants and may influence hormonal and nervous system activity.

• Improved Behavior and Activity: Mice given raspberry flavonoids were more active and curious than untreated mice, suggesting potential benefits for energy and mood during hormonal changes.

• Better Memory Performance: The flavonoid-treated mice performed better in memory tests, indicating a possible positive effect on cognitive function during perimenopause.

• Hormone Levels: The raspberry flavonoids helped bring hormone levels (such as estrogen and testosterone) closer to normal and reduced elevated levels of hormones that usually increase during perimenopause in this model.

• Organ and Tissue Health: Mice given raspberry flavonoids showed healthier ovaries, uterus, thymus, and spleen compared with untreated mice, suggesting protective effects on tissues impacted by hormonal decline.

In this animal study, raspberry flavonoids showed positive effects on behavior, hormone balance, and organ health in a model of perimenopause. The findings suggest that compounds in raspberries might offer support for symptoms related to hormonal changes, at least in this experimental setting.

Important Note: These results come from a mouse model, not human subjects. Human studies are needed to confirm whether similar benefits occur in people.